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@article{189693,
        author = {Rohit D. Patil},
        title = {Unlocking Potential: Cocrystals as catalyst for heightened solubility and dissolution of low solubility pharmaceuticals.},
        journal = {International Journal of Innovative Research in Technology},
        year = {2025},
        volume = {12},
        number = {7},
        pages = {7528-7539},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=189693},
        abstract = {The abstract provides an overview of solubility in pharmaceuticals, emphasizing its significance and challenges. It discusses the importance of drug solubility in dosage frequency and bioavailability, highlighting the prevalence of solubility issues in marketed drugs. The framework for classifying biopharmaceuticals (BCS) categorizes medicines determined by solubility and permeability, guiding formulation strategies. Cocrystals offer a promising approach to address solubility challenges, providing a rational means to modify drug properties. The abstract explores the definition and potential of cocrystals in various applications, with a focus on pharmaceuticals. It examines the mechanisms of cocrystal formation and their impact on drug solubility enhancement. Various cocrystallization techniques, including solution-based and solid-state methods, are discussed, along with analytical techniques for characterization. Case studies on AZL-NA and lopinavir-menthol cocrystals highlight the efficacy of cocrystal technology in improving drug properties. Future prospects for cocrystal engineering involve overcoming commercialization challenges and scaling up production. Computer-assisted techniques and continuous processes offer promising avenues for advancing cocrystal technology. Overall, cocrystal engineering presents a viable strategy for enhancing drug solubility and bioavailability, potentially leading to the development of novel and improved pharmaceutical formulations.},
        keywords = {Bioavailability, Cocrystals, Drug formulation, pharmaceutical technology, Solubility.},
        month = {December},
        }