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@article{189830,
        author = {Dr. PRATHAP P B and Raghuram K A and Dr. Sushma N and Dr. Deepika K C and Dr. Santhosh Kumar K B},
        title = {Tilted Fiber Bragg Grating Biosensor with Peak-Tracking for Troponin-T Based Heart Disease Detection},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {4655-4662},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=189830},
        abstract = {The prevalence of cardiovascular diseases has been increasing, particularly among individuals aged 35–45 years. Disorders such as Coronary Artery Disease (CAD) and Cerebrovascular Disease (CVD) often result in myocardial injury due to inadequate oxygen supply, leading to heart attacks. Cardiac Troponin-T (cTnT) serves as a specific and reliable biomarker for detecting cardiac muscle damage, as it is released into the bloodstream only after myocardial cell injury. This paper proposes a highly sensitive gold-coated Tilted Fiber Bragg Grating (TFBG) biosensor with an optimized tilt angle of 11° for efficient detection of cTnT. A single-stranded DNA aptamer immobilized on a 0.02 mm gold layer via gold–thiol bonding exhibits strong and selective binding affinity toward cTnT within the concentration range of 0.05–5 ng/mL. The aptamer–protein interaction modifies the refractive index of the coating, resulting in a wavelength shift in the TFBG spectrum. RCC-correlation using the Mexican-Hat wavelet enhances peak tracking accuracy near the Bragg wavelength. Simulation results demonstrate that the proposed sensor achieves high sensitivity and stability, enabling precise and early diagnosis of cardiac disorders.},
        keywords = {Aptamer Sequence, Fiber Bragg Grating, Biosensor, Gold Encapsulation, Peak Tracking, Refractive Index, Troponin-T.},
        month = {January},
        }