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@article{190480,
        author = {Krushnali Chavan and Puja G. Vyawhare and Vedantee Chavan and Shravani Dhamal and Divya Kori and Rupali R. Tasgaonkar},
        title = {A paradigm shift in immunization mRNA vaccine technology beyond covid-19},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {1287-1292},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=190480},
        abstract = {The rapid and successful deployment of messenger RNA (mRNA) vaccines against the SARS-CoV-2 virus marked a pivotal moment in vaccinology, fundamentally shifting the paradigm for immunization and therapeutic development. Initially relegated to niche research, the technology demonstrated unprecedented speed, flexibility, and efficacy during the COVID-19 pandemic. This review explores the fundamental molecular architecture and mechanism of mRNA vaccines, focusing on the critical role of lipid nanoparticle (LNP) delivery systems. Crucially, it examines the vast therapeutic landscape now being aggressively explored beyond infectious disease prevention, including personalized cancer immunotherapy, prophylaxis against persistent pathogens like HIV and influenza, and treatments for genetic disorders. Despite challenges related to stability and manufacturing costs, ongoing innovations in RNA design (e.g., self-amplifying mRNA) and delivery platforms suggest that mRNA technology is poised to become a core pillar of twenty-first-century precision medicine.},
        keywords = {Cancer immunotherapy, COVID19, immunisation, infectious disease, lipid nanoparticles, mRNA vaccines, Neoantigens, precision medicines, Selfamplifying mRNA, vaccine delivery systems.},
        month = {January},
        }