Environmentally Friendly Schiff Base–Metal Complexes: Promising Agents against Pathogens and Cancer Cells

  • Unique Paper ID: 190901
  • PageNo: 4323-4329
  • Abstract:
  • A mixed ligand complex was synthesized using the Schiff base ligand p-Methoxy Isonitrosoacetophenone (p-MINAP), prepared by the reaction of p-Methoxyacetophenone with n-amyl nitrite, as the primary ligand, and 1,10-Phenanthroline (1,10-Phen) as the secondary ligand. The Schiff base ligand and the resulting mixed ligand complex were characterized through elemental analysis, IR, UV-Visible spectroscopy, ¹H NMR, molar conductance, and magnetic moment studies. The mixed ligand complex was found to have the general formula [M(p-MINAP)(1,10-Phen)], with an octahedral geometry around the metal center. The synthesized Schiff base (p-MINAP), the 1,10-Phenanthroline ligand, and their mixed ligand complex were evaluated for antibacterial and antifungal activities against both Gram-positive and Gram-negative bacteria, as well as fungi. The results revealed significant antimicrobial activity of the synthesized compounds.

Copyright & License

Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

BibTeX

@article{190901,
        author = {Gajbhiye R. G.},
        title = {Environmentally Friendly Schiff Base–Metal Complexes: Promising Agents against Pathogens and Cancer Cells},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {4323-4329},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=190901},
        abstract = {A mixed ligand complex was synthesized using the Schiff base ligand p-Methoxy Isonitrosoacetophenone (p-MINAP), prepared by the reaction of p-Methoxyacetophenone with n-amyl nitrite, as the primary ligand, and 1,10-Phenanthroline (1,10-Phen) as the secondary ligand. The Schiff base ligand and the resulting mixed ligand complex were characterized through elemental analysis, IR, UV-Visible spectroscopy, ¹H NMR, molar conductance, and magnetic moment studies.
The mixed ligand complex was found to have the general formula [M(p-MINAP)(1,10-Phen)], with an octahedral geometry around the metal center. The synthesized Schiff base (p-MINAP), the 1,10-Phenanthroline ligand, and their mixed ligand complex were evaluated for antibacterial and antifungal activities against both Gram-positive and Gram-negative bacteria, as well as fungi. The results revealed significant antimicrobial activity of the synthesized compounds.},
        keywords = {Schiff base, p-MINAP, 1,10-Phenanthroline, Mixed ligand complex.},
        month = {January},
        }

Cite This Article

G., G. R. (2026). Environmentally Friendly Schiff Base–Metal Complexes: Promising Agents against Pathogens and Cancer Cells. International Journal of Innovative Research in Technology (IJIRT), 12(8), 4323–4329.

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