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@article{190915,
        author = {Katkar Sujata Dayanand and Syed Abdul Azeem A. and Suryawanshi Reshma B. and Jalne Gangasagar B. and Jawalekar Ganesh A. and Chavan janhavi G.},
        title = {A comprehensive review on Mucoadhesive gel},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {8},
        pages = {5447-5454},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=190915},
        abstract = {Mucoadhesive gels have emerged as one of the most promising dosage forms in Controlled and localized drug delivery, owing to their ability to adhere to mucosal Surfaces and provide prolonged therapeutic effects. The concept of mucoadhesion, First introduced in the 1980s, involves the interaction between polymeric materials And mucin present on the epithelial surface, leading to extended residence time and Enhanced bioavailability of drugs administered through mucosal routes such as Buccal, nasal, vaginal, ocular, and rectal pathways . These systems combine the Advantages of both gels and mucoadhesive polymers, offering improved patient Compliance, ease of administration, and effective site-specific delivery .Formulation of mucoadhesive gels involves selecting appropriate natural or Synthetic polymers such as carbopol, chitosan, hydroxypropyl methylcellulose (HPMC), sodium alginate, and polycarbophil, which determine rheological Behavior, swelling capacity, and mucoadhesive strength . The Physicochemical characteristics of these polymers—such as molecular weight, Degree of cross-linking, and charge—significantly influence the adhesion Mechanism and drug release profile . Several methods, including cold or hot Mechanical stirring, dispersion, and solvent evaporation, are employed to prepare These gels depending on the polymer and drug used .The mechanism of mucoadhesion primarily involves wetting, adsorption, and Interpenetration between the polymer and mucin chains, resulting in non-covalent Interactions such as hydrogen bonding, van der Waals forces, and electrostatic Attractions . Evaluation of mucoadhesive gels includes determining parameters
Such as viscosity, spreadability, swelling index, pH, drug content uniformity, invitro drug release, and ex-vivo mucoadhesive strength using models like porcine or Goat mucosa},
        keywords = {Mucoadhesive gels, bioadhesion, drug delivery, polymers, mucosal Routes, formulation, evaluation},
        month = {January},
        }