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@article{192238,
        author = {Rushikesh Chavan and Sanchi Dayanand Kamble},
        title = {Nanoparticle-Mediated Strategies for Targeted Drug Transport Across the Blood–Brain Barrier},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {9},
        pages = {1124-1136},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=192238},
        abstract = {The blood–brain barrier (BBB) is a highly dynamic and selectively permeable interface that safeguards the central nervous system (CNS). It plays a vital role in protecting neural tissue from toxins, pathogens, and fluctuations in blood composition, while also regulating the transport of essential nutrients and maintaining overall brain homeostasis. At the same time, this remarkable protective function creates a major therapeutic challenge: most drugs cannot efficiently cross the BBB. In fact, conventional small molecules, peptides, proteins, and gene-based therapeutics generally fail to reach the brain in concentrations sufficient to achieve meaningful clinical effects. This limitation has significantly hindered the treatment of neurological conditions such as Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, epilepsy, stroke, and brain tumors.
This review highlights recent progress in the field of NP-mediated drug transport across the BBB, presented in four key stages: (1) the structure and physiology of the BBB and the barriers it imposes to drug delivery; (2) nanoparticle platforms and targeting strategies; (3) preclinical models and progress toward clinical translation; and (4) future innovations, including gene-editing technologies and AI-guided nanomedicine.},
        keywords = {Brain, Nanoparticles, Blood brain barrier},
        month = {February},
        }