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@article{192533,
        author = {Sakshi killedar and Reema rani and Dr Rupali Tasgaonkar},
        title = {Role of alkaloids in depression},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {9},
        pages = {1736-1740},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=192533},
        abstract = {Depression is a common neuropsychiatric disorder that profoundly impacts quality of life and continues to be one of the most serious health problems worldwide. Conventional antidepressant drugs, while effective, present several disadvantages, such as delayed onset of action, frequent side effects, and incomplete response in a large number of patients. Over recent years, interest has shifted toward medicinal plant-derived alkaloids for their potential antidepressant activity. The extracts of these compounds exhibit multiple mechanisms of action, including the regulation of monoamine neurotransmitters, inhibition of monoamine oxidase enzymes, antioxidant activity, and modulation of neuroinflammation pathways. Various alkaloids are discussed here for their role in managing depression, along with modes of their action and advantages over synthetic antidepressants. The article further discusses future perspectives by emphasizing the need for advanced pharmacological research and with better designs to confirm the safety and efficacy of alkaloids as promising antidepressant therapeutic agents.},
        keywords = {Neuropsychiatric, Antidepressant drug, Neurotrasmitter, Neuroinflammation.},
        month = {February},
        }