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@article{193058,
        author = {Om Prakash Lekhrao and Sumit Nathani},
        title = {Evaluation of Anti-Proliferative and Anxiolytic Action of Mandukaparni Sadhita Ghrita in Imiquimod-Induced Psoriasis in Albino Wistar Rats – An In-Vivo Experimental Study},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {9},
        pages = {4403-4412},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=193058},
        abstract = {Background: Psoriasis is a chronic immune-mediated inflammatory skin disorder characterized by keratinocyte hyperproliferation and psychological stress.  , In Ayurveda, psoriasis resembles Eka Kushtha, a Vata-Kapha predominant disorder.  Mandukaparni (Centella asiatica) is described as Medhya Rasayana and Kushthaghna drug.  Ghrita acts as an ideal vehicle enhancing bioavailability. 
Objective: To evaluate the anti-proliferative and anxiolytic action of Mandukaparni Sadhita Ghrita in imiquimod-induced psoriasis in Albino Wistar rats.
Methods: Psoriasis was induced using 5% imiquimod cream. Forty-two rats were divided into seven groups (n=6): induced control, oral test drug, topical test drug, combined oral + topical test drug, oral standard (methotrexate), topical standard (hydrocortisone), and combined standard group. Anti-psoriatic activity was assessed using PASI score and histopathological parameters. Anxiolytic activity was evaluated using Light and Dark Box test. Statistical analysis was performed using one-way ANOVA followed by Dunnett’s test.
Results: Mandukaparni Sadhita Ghrita significantly reduced PASI score and histopathological severity compared to induced control. Combined oral and topical administration showed better improvement than individual routes. Behavioral tests revealed increased time spent in light chamber and increased transitions indicating anxiolytic activity. Standard drugs showed maximum effect, while test drug groups showed moderate but significant improvement.
Conclusion: Mandukaparni Sadhita Ghrita possesses anti-proliferative and anxiolytic activity in experimental psoriasis and may serve as a safe Ayurvedic therapeutic option for managing psoriasis with psychological comorbidity.},
        keywords = {Psoriasis, Eka Kushtha, Mandukaparni Sadhita Ghrita, Imiquimod model, Anti-proliferative, Anxiolytic activity,Ayurveda},
        month = {February},
        }