Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{193266,
        author = {Priyanka Sawant and Sachin Yadav and Leena Thakare},
        title = {GANGRENE: A REVIEW ON PATHOGENESIS AND ITS IMPACT ON PUBLIC HEALTH},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {9},
        pages = {4494-4501},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=193266},
        abstract = {Gangrene is a severe and potentially fatal condition characterized by the death of body tissue resulting from infection, ischemia, or trauma. It poses a significant threat to global public health, particularly among populations with diabetes, peripheral arterial disease, and poor socioeconomic conditions. This review provides a comprehensive overview of the pathogenesis, types, clinical manifestations, epidemiology, and management of gangrene, including dry, wet, gas, Fournier’s, and internal forms. The underlying mechanisms involve impaired blood circulation, bacterial infection—especially by Clostridium perfringens—and systemic inflammatory responses leading to tissue necrosis. Early diagnosis, surgical debridement, fluid resuscitation, and broad-spectrum antibiotic therapy remain the cornerstones of management. Emerging treatment modalities such as hyperbaric oxygen therapy, nanotechnology, and stem cell therapy show promise in enhancing wound healing and tissue regeneration. Preventive strategies, including blood sugar control, smoking cessation, and proper wound care, are critical for reducing disease burden. A multidisciplinary and proactive approach is essential to improve prognosis, minimize amputations, and lower mortality rates associated with gangrene.},
        keywords = {Gangrene; Pathogenesis; Tissue necrosis; Clostridium perfringens; Public health; Diabetes; Peripheral artery disease; Hyperbaric oxygen therapy; Surgical debridement; Wound management; Infection control; Prevention.},
        month = {February},
        }