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@article{193318,
        author = {Nikita Sanjay Salekar and Gaikwad kirti Sudhakar and Ubale Nikita sudhakar and Najan Sumit Suresh and Shirsath Rameshwar Vishnu},
        title = {DEVELOPMENT OF TRANSDERMAL PATCH OF CAFFEINE FOR ALERTNESS ENHANCEMENT},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {10},
        pages = {90-97},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=193318},
        abstract = {Fatigue, drowsiness, and reduced alertness are common problems affecting students, professionals, and shift workers. Caffeine is a widely used central nervous system stimulant that improves wakefulness, attention, and cognitive performance. Conventional oral caffeine formulations provide rapid stimulation but produce fluctuations in plasma concentration, gastrointestinal irritation, and dependence. Therefore, a controlled drug delivery system such as transdermal patch can provide sustained drug release and improved patient compliance.
The present study aimed to develop and evaluate a transdermal patch containing caffeine for alertness enhancement. The patches were prepared using solvent casting method with suitable polymers and plasticizers. The prepared patches were evaluated for thickness, weight variation, folding endurance, moisture content, drug content, in-vitro drug release, and skin permeation. The results indicated that the developed patch showed uniform physicochemical properties and sustained drug release for 24 hours. The study concludes that transdermal caffeine patch can be considered a promising alternative to oral caffeine formulations for prolonged alertness enhancement.},
        keywords = {Caffeine, Transdermal patch, Alertness, Sustained release, CNS stimulant, Drug delivery system},
        month = {March},
        }