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@article{193404,
        author = {Naman N. Bisen and Roshani D. Agrawal and Dr. Tulsidas P.Nimbekar},
        title = {A Review on solubility enhancement techniques},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {10},
        pages = {285-296},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=193404},
        abstract = {Solubility enhancement is a critical strategy in pharmaceutical development, as a significant proportion of newly discovered drug candidates exhibit poor aqueous solubility, leading to low bioavailability and reduced therapeutic efficacy. Various techniques have been developed to overcome solubility limitations and improve drug absorption. These approaches are broadly categorized into physical, chemical, and formulation-based methods. Physical modifications include particle size reduction (micronization and nanonization), solid dispersion formation, and crystal engineering. Chemical methods involve salt formation, prodrug synthesis, and pH adjustment to improve dissolution characteristics. Formulation strategies such as the use of surfactants, co- solvents, complexation (e.g., cyclodextrin inclusion complexes), lipid-based drug delivery systems, and self-emulsifying drug delivery systems (SEDDS) further enhance solubility and dissolution rates. Advanced techniques like supercritical fluid technology and nanotechnology-based carriers also show promising results. The selection of an appropriate solubility enhancement method depends on the physicochemical properties of the drug, route of administration, and desired pharmacokinetic profile.},
        keywords = {solubility enhancement, bcs classification, ph adjustment, co-solvency, co-crystalization, solubilizing, formation of salt, surfactant, solvent evaporation, micro-emulsion, co-micronization, nano-emulsion, homogenization, spray drying, hydrotrophy.},
        month = {March},
        }