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@article{193612,
        author = {Abhishek Dilip Gandhi and Prof Amol G Jadhao},
        title = {Comparative Evaluation of Thermoplastic Granulation Techniques on Tablet Properties of Meloxicam},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {10},
        pages = {2089-2093},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=193612},
        abstract = {Meloxicam, a widely used nonsteroidal anti-inflammatory drug, exhibits poor aqueous solubility and high crystallinity, which limit its dissolution rate and oral bioavailability when formulated as conventional tablets. The present study aimed to evaluate the effectiveness of thermoplastic granulation techniques in improving the tablet properties of meloxicam. Melt granulation, melt agglomeration, and hot-melt extrusion were employed as solvent-free processing methods using suitable thermoplastic binders and polymers. The prepared granules and tablets were evaluated for pre-compression parameters, post-compression characteristics, and in vitro dissolution behavior. Results demonstrated significant improvement in flowability, compressibility, mechanical strength, and dissolution performance for thermoplastic granulated formulations compared to conventional approaches. Among the evaluated techniques, hot-melt extrusion showed superior enhancement in dissolution and overall tablet quality. The study concludes that thermoplastic granulation techniques represent efficient and scalable strategies for improving the formulation performance of poorly soluble analgesic drugs such as meloxicam, with strong potential for industrial application.},
        keywords = {Meloxicam; Thermoplastic granulation; Melt granulation; Hot-melt extrusion; Dissolution enhancement; Tablet properties},
        month = {March},
        }