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@article{194177,
        author = {Dr Sunil Firangi and Syed Zakir Hussain and Dr Maruti T Ekbote},
        title = {DESIGN AND INVITRO CHARACTERISTICS OF SUSTAINED RELEASE SUMATRIPTAN SUCCINATE TABLETS},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {10},
        pages = {2786-2790},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=194177},
        abstract = {The goal of the present study is to create a sustained release tablet dosage form for the anti-migraine medication Sumatriptan Succinate, which agonistically acts on 5-HT receptors. The wet granulation method was used to prepare the tablets, and different concentrations amounts of polymers, including HPMC K4M, ethyl cellulose, and Eudragit RSPO. In order to ensure flow characteristics during punching of tablets, the formulated sustained release tablets were assessed for precompression parameters like bulk & tapped densities, Hausners ratio, Carrs index and Angle of repose. The tablets were assessed for physicochemical characteristics, including stability studies, weight fluctuation, thickness uniformity, and hardness. When compared to other formulations, the findings from in vitro release experiments demonstrated that formulation SSF7, which contained 50 mg of each of HPMC K4M, ethyl cellulose, and eudragit RSPO, demonstrated an acceptable outcome and optimal 95% of drug release after 12 hours. All formulations meet the Higuchi model, according to the drug release kinetic data. To analyze the drug's release mechanism from the polymeric system, the findings of in-vitro drug release data were fitted to Korsmeyer Peppa's model, which showed that the drug release followed a Fickian release mechanism. By bypassing first-pass metabolism, Sumatriptan Succinate has a longer therapeutic impact and improves patient compliance.},
        keywords = {Sumatriptan Succinate, HPMC K4M, Ethyl cellulose, Eudragit},
        month = {March},
        }