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@article{194510,
        author = {Mantena Jayanth Siva Sai Varma},
        title = {SYNTHESIS AND CHARACTERIZATION OF BIOFUNCTIONALIZED ZnO NANOPARTICLES AND THEIR BIOPHYSICAL IMPACT ON CANCER CELLS},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {10},
        pages = {3934-3944},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=194510},
        abstract = {Zinc oxide nanoparticles (ZnO NPs) exhibit unique physicochemical and biological properties, making them promising candidates in oncology. These characteristics make them good candidates for cancer diagnosis and treatment. Their small size, large surface area, and semiconducting properties allow them to interact effectively with cells. Additionally, their natural ability to produce reactive oxygen species (ROS) leads to selective toxicity against cancer cells. Current research heavily focuses on their synthesis. Green and biogenic methods are becoming more popular because they are eco-friendly, cost-effective, and safe for living organisms. These methods use plant extracts, microbes, or biomolecules, which reduce the need for harmful chemicals and improve the safety of ZnO NPs, thus lowering overall toxicity. In cells, ZnO NPs work against cancer by creating oxidative stress, disrupting mitochondrial function, and activating apoptosis pathways. Moreover, attaching proteins, polysaccharides, and therapeutic agents to ZnO NPs improves their stability, targeting ability, and drug delivery potential. The use of artificial intelligence (AI) and computer modeling has also transformed their applications, allowing for accurate predictions of how nanoparticles interact with cells, optimizing dosages, and developing personalized treatment strategies.},
        keywords = {Zinc Oxide Nanoparticles, Precision Nanomedicine, Cytotoxicity, Drug Delivery.},
        month = {March},
        }