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@article{195262,
        author = {KIRUTHIKA KUMARAVEL and KRITHIKA SEENIVASAN and KOFIANNAN PICHAMUTHU and DR. DEEPSHIKA SARAVANAN and Dr. MARIA SUBASH AARON M},
        title = {EFFECTS OF PERIODONTITIS ON SYSTEMIC HEALTH},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {10},
        pages = {7408-7418},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=195262},
        abstract = {Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth, including the gingiva, periodontal ligament, and alveolar bone. Beyond its local effects in the oral cavity, increasing evidence indicates that periodontitis has significant systemic implications. The dissemination of periodontal pathogens and inflammatory mediators into the bloodstream can contribute to the development or progression of several systemic conditions. This article reviews the relationship between periodontitis and various systemic diseases such as diabetes mellitus, hypertension, cardiovascular disease, metabolic syndrome, rheumatoid arthritis, chronic obstructive pulmonary disease, chronic kidney disease, malignancy and adverse pregnancy outcomes. The mechanisms underlying these associations include systemic inflammation, immune dysregulation, oxidative stress, and endothelial dysfunction triggered by periodontal infection. A bidirectional relationship has been particularly observed between periodontitis and certain systemic diseases, notably diabetes mellitus and metabolic syndrome. Understanding the link between oral health and systemic health highlights the importance of early diagnosis and effective management of periodontal disease. Maintaining periodontal health may therefore contribute not only to preserving oral structures but also to improving overall systemic health and quality of life.},
        keywords = {Periodontitis, Systemic health, Diabetes Mellitus, Cardiovascular disease, Hypertension, Adverse pregnancy outcomes, COPD, Rheumatoid arthritis, Malignancy.},
        month = {March},
        }