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@article{195387,
        author = {Bhumika L Sewake and Dr. Pankaj M. Pimpalshende},
        title = {Mucoadhesive Buccal Drug Delivery Systems of Glycyrrhiza glabra (Liquorice) for Sustained Anti-Ulcer Therapy: A Comprehensive Review},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {11},
        pages = {20-25},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=195387},
        abstract = {Peptic ulcer disease is still a common gastrointestinal condition with high recurrence rates and drawbacks to traditional treatments, such as frequent dosage, systemic adverse effects, and decreased bioavailability because of first-pass metabolism. These difficulties call for the creation of sophisticated medication delivery methods that can enhance patient compliance and offer long-lasting therapeutic efficacy. Mucoadhesive buccal drug delivery systems have shown promise in this regard, providing regulated drug release, extended residence time, and avoidance of hepatic metabolism. The well-known medicinal herb Glycyrrhiza glabra, or liquorice, has strong gastroprotective properties that are ascribed to its bioactive components, which include glycyrrhizin, flavonoids, and saponins. Through a variety of mechanisms, such as cytoprotection, anti-inflammatory action, and antioxidant activity, these substances have anti-ulcer benefits. Liquorice improves stability, bioavailability, and sustained release properties in mucoadhesive buccal formulations, increasing their therapeutic potential.
The scientific underpinnings of mucoadhesion, formulation techniques, and design factors for buccal drug delivery systems are highlighted in this review, along with their therapeutic efficacy in the treatment of ulcers. Future prospects for clinical translation and commercialization are also covered, along with current research and scale-up issues and emerging trends like smart polymers and nano-enabled systems. All things considered, liquorice-based mucoadhesive buccal systems are an innovative and successful method of long-term anti-ulcer therapy with great potential for incorporation into contemporary healthcare.},
        keywords = {Mucoadhesion, Liquorice, Glycyrrhiza glabra, Peptic ulcer.},
        month = {March},
        }