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@article{200570,
        author = {Vaishnavi Balkrishna Tribhuwan and Shantanu Devidas Unche and Dhanashree Sudhakar Waghmode and SHRADDHA BANDU WAKLE and Laveena Makhija},
        title = {Ibuprofen-Loaded Nanogels: Advancing Topical Therapy Through Nanoengineered Drug Delivery Systems},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {12},
        pages = {2231-2251},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=200570},
        abstract = {Ibuprofen, a commonly used non-steroidal anti-inflammatory drug (NSAID), exhibits limitations such as poor aqueous solubility (BCS Class II), short half-life, and gastrointestinal side effects, which restrict its therapeutic efficiency. To overcome these challenges, ibuprofen-loaded nanogels have been developed as an advanced drug delivery system for enhanced localized and transdermal delivery. These nanogels are prepared using high-energy methods (such as high-pressure homogenization, microfluidization, and ultrasonication) and low-energy techniques (including phase inversion and self-nanoemulsification), forming a stable three-dimensional polymeric network with key excipients like Carbopol 934 and Tween 80. With particle sizes ranging from 20–200 nm, nanogels improve solubility, provide high drug encapsulation efficiency (>90%), and enable controlled drug release following Higuchi and Korsmeyer–Peppas kinetics. Overall, ibuprofen nanogels enhance dermal permeation, ensure sustained drug release, reduce dosing frequency, and minimize systemic side effects, making them a promising approach for the treatment of localized inflammatory conditions.},
        keywords = {Ibuprofen, Nanogel, Nanoemulsion, Transdermal Delivery, Carbopol 934, NSAIDs, Controlled Release.},
        month = {May},
        }