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@article{202026,
        author = {Sunil. D. Hilli and Abhishek. D. Jadhav and Ashitosh. S. Humbare and Nikita. N. Ingale and Payal. R. Gharde and Prof. Sushma. T. Nakhate and Principal. Dr. Tushar. T. Shelke},
        title = {Formulation and Evaluation of a Natural Anti-Diabetic Nutraceutical Powder},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {12},
        number = {12},
        pages = {6075-6092},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=202026},
        abstract = {Formulation and Evaluation of a Natural Anti-Diabetic Nutraceutical Powder
Diabetes mellitus remains a significant global health challenge, particularly Type 2 diabetes, which accounts for the vast majority of cases. Conventional pharmaceutical treatments, while effective, often require lifelong adherence and may carry side effects. This research aimed to formulate and evaluate a natural, effective nutraceutical powder dosage form designed to assist in maintaining blood sugar levels and preventing diabetes complications. The term "nutraceutical" refers to products derived from food sources that provide extra health benefits beyond basic nutrition, and this study leverages their potential as a preventive and management strategy.
The formulation was developed following an extensive literature survey to identify herbal ingredients with proven anti-diabetic properties, such as *Moringa oleifera* (Drumstick), *Syzygium cumini* (Jamun), and *Phyllanthus emblica* (Amla). Specifically, the optimized formulation utilized 46.65% Moringa leaves powder, 33.35% Jamun seed powder, and 20% Amla powder. The preparation involved collecting healthy Moringa leaves, which were washed with distilled water, shade-dried to prevent the degradation of active constituents, and milled to a uniform particle size. All herbal materials were passed through a sieve to ensure uniformity and blended using a geometric mixing method to achieve a homogeneous powder.
Evaluation of the formulated powder included organoleptic, physicochemical, and flow property testing. Initial results showed an olive-green powder with a characteristic odor and a slightly bitter, earthy taste. The suspension was found to be acidic with a pH of 2.16. Early assessments of flow properties revealed a "Poor" rating, with an angle of repose of 41.34 and a compressibility index of 37.31. To optimize the formulation for commercial feasibility, a 1% w/w glidant (Talc) was added. This modification significantly improved the flow properties to a "Good" rating, reducing the angle of repose to 33.42 and the compressibility index to 19.4.
The medicinal efficacy of the selected ingredients is supported by their various mechanisms of action, such as stimulating insulin secretion from pancreatic beta cells, enhancing glucose uptake, and inhibiting enzymes like \alpha-amylase. For instance, Moringa leaves provide essential antioxidants and anti-inflammatory properties, while Jamun seeds and Amla contribute to glucose homeostasis and immune support. This research concludes that the developed herbal nutraceutical powder is a stable and promising alternative for diabetes management, offering the benefits of preventive care with minimal side effects. The study successfully meets its objective of creating a standardized herbal formulation that is both palatable and physically stable.},
        keywords = {Nutraceutical, Diabetes Mellitus (Type 2) Anti-diabetic Herbs (e.g., Karela, Jamun, Methi)  Herbal Formulation Moringa oleifera  Amla (Phyllanthus emblica) Phytochemicals a-Amylase Inhibition Physicochemical Evaluation Antioxidant Preventive Care},
        month = {May},
        }