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@article{203808,
        author = {Miss. Rupali Babasaheb Pathade and Ass. Prof. Miss. Priti Ambhore},
        title = {FORMULATION AND EVALUATION OF CURCUMIN NANOSUSPENTION GEL FOR ANTI-INFLAMMATORY ACTIVITY},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {237-251},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=203808},
        abstract = {Curcumin, a naturally occurring polyphenolic compound obtained from Curcuma longa, possesses significant anti-inflammatory, antioxidant, antimicrobial, and wound-healing properties. However, its therapeutic application is greatly limited due to poor aqueous solubility, low permeability, rapid metabolism, and poor oral bioavailability. The present study was aimed at the formulation and evaluation of a curcumin nanosuspension-loaded gel for enhanced bioavailability and improved therapeutic efficacy through topical delivery.
 Curcumin nanosuspension was prepared using the nanoprecipitation/high-speed homogenization method with suitable stabilizers and surfactants to reduce particle size and improve drug dispersion. The prepared nanosuspension was evaluated for particle size, polydispersity index, zeta potential, drug content, entrapment efficiency, and in vitro drug release. The optimized nanosuspension exhibited nanosized particles with uniform distribution, good stability, and enhanced dissolution behavior compared to pure curcumin. The optimized curcumin nanosuspension was further incorporated into a gel base using suitable gelling agents to obtain a stable topical formulation. The prepared gel formulations were evaluated for physical appearance, pH, viscosity, spreadability, homogeneity, drug content, extrudability, and stability studies. In vitro diffusion studies demonstrated sustained and enhanced release of curcumin from the nanosuspension gel formulation. Ex vivo permeation studies indicated improved skin penetration and bioavailability due to the nanosized drug particles and increased surface area. The results of the study confirmed that nanosuspension-based gel formulation significantly improved the solubility, dissolution rate, and topical bioavailability of curcumin compared to conventional formulations. Hence, the developed curcumin nanosuspension gel may serve as a promising drug delivery system for effective topical therapy with enhanced therapeutic performance and patient compliance.},
        keywords = {Curcumin, Nanosuspension, Gel, Bioavailability, Topical Drug Delivery, Nanotechnology, In Vitro Release, Skin Permeation.},
        month = {June},
        }