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@article{203934,
        author = {Vishal Bharat Kadam and Dr. Ajay Digambar Kshirsagar},
        title = {DESIGN DEVELOPMENT AND CHARACTERIZATION OF GASTRO-RETENTIVE BILAYER FLOATING TABLETS},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {1385-1399},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=203934},
        abstract = {The present study focuses on the design, development, and characterization of gastro-retentive bilayer floating tablets of Lisinopril for improved therapeutic efficacy and controlled drug release. The formulation was developed to achieve a dual-release pattern consisting of an immediate release layer for rapid onset of action and a sustained release floating layer for prolonged drug delivery. The immediate release layer was formulated using super disintegrants such as sodium starch glycolate and croscarmellose sodium, while the sustained release layer was prepared using hydrophilic polymers including HPMC K100M and HPMC K4M along with sodium bicarbonate as a gas-generating agent. Preformulation studies confirmed the purity, compatibility, and suitability of Lisinopril for formulation development. The prepared powder blends exhibited good flow properties, ensuring uniform compression. The bilayer tablets were evaluated for physicochemical parameters such as hardness, friability, weight variation, thickness, drug content, and swelling index, all of which were found to be within acceptable limits. In-vitro dissolution studies demonstrated a biphasic drug release pattern with rapid initial release followed by sustained release up to 12 hours. Among all formulations, the optimized formulation (FE2) showed approximately 94% cumulative drug release with desirable floating and swelling characteristics. Drug release kinetics revealed that the formulation followed zero-order kinetics and Korsmeyer–Peppas model, indicating anomalous (non-Fickian) diffusion mechanism. Stability studies confirmed that the optimized formulation remained stable under accelerated conditions without significant changes in physicochemical properties or drug release profile. Overall, the developed gastro-retentive bilayer floating tablet system of Lisinopril provides an effective approach for enhancing bioavailability, prolonging gastric residence time, and improving patient compliance.},
        keywords = {Gastro-retentive drug delivery system; Bilayer tablets; Floating drug delivery system; Lisinopril; Sustained release; Immediate release; HPMC; Drug release kinetics; Non Fickian diffusion; Swelling index.},
        month = {June},
        }