Copyright © 2026 Authors retain the copyright of this article. This article is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

@article{204577,
        author = {Dr. BRUNDA. M S and Kavana Shree Y and Dr. Biswajith and Dr. Prathyusha and Dr. Jagadhish},
        title = {SEVERE AMLODIPINE OVERDOSE PRESENTING WITH REFRACTORY HYPOTENSION: A CASE REPORT},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {4385-4388},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=204577},
        abstract = {Amlodipine overdose is a life-threatening condition that can lead to severe vasodilation, refractory hypotension, and multi-organ dysfunction. Prompt diagnosis and aggressive management are essential to improve outcomes. We report a case of a 29-year-old female who presented with deliberate self-harm following ingestion of approximately 60 tablets of amlodipine (5mg) corresponding to a total dose of about 300 mg. The patient was admitted with symptoms of dizziness, throat pain, chills, and profound hypotension. On admission, vital signs revealed hypotension (BP 70/50 mmHg), bradycardia (HR 62 bpm initially), and oxygen saturation of 85% on room air. Initial laboratory investigations showed leukocytosis, mild anemia, metabolic abnormalities, and reduced ionized calcium levels.
The patient required intensive care management including gastric lavage, intravenous fluids, vasopressor support with norepinephrine, calcium gluconate administration, and high-dose insulin therapy with glucose supplementation. Due to persistent hemodynamic instability, mechanical ventilation and multiple sessions of plasmapheresis were performed. Further supportive management included electrolyte correction, antibiotics, and close monitoring of organ function. Imaging studies including chest radiography and echocardiography showed no significant cardiac abnormalities with preserved ejection fraction.
With aggressive supportive care, the patient gradually improved clinically and was successfully extubated. She remained hemodynamically stable and was discharged with appropriate follow-up advice. This case highlights the importance of early recognition and multidisciplinary management in severe amlodipine poisoning.},
        keywords = {Amlodipine toxicity, Anemia, Hypotension, High-dose insulin therapy, Plasmapheresis, Hyperglycemia.},
        month = {June},
        }