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@article{204693,
        author = {Murdare Aditya Rajendra},
        title = {Acacia Gum-Based Self-Healing Hydrogels for Wound, Burn and Ulcer Management: A Comprehensive Review},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {3363-3371},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=204693},
        abstract = {Wound healing remains a complex biological process involving hemostasis, inflammation, proliferation, and tissue remodeling. Chronic wounds, burn injuries, and ulcerative lesions continue to represent a major healthcare challenge worldwide due to delayed healing, microbial infections, excessive inflammation, and increasing healthcare costs. Conventional wound dressings often exhibit limitations such as poor moisture retention, inadequate drug release, frequent replacement requirements, and limited tissue regeneration capabilities. Consequently, considerable attention has been directed toward the development of advanced biomaterials capable of promoting effective wound management and tissue repair. Acacia gum, a naturally occurring polysaccharide obtained primarily from Acacia senegal and Acacia seyal, has emerged as a promising biomaterial for biomedical applications because of its biocompatibility, biodegradability, non-toxicity, mucoadhesive properties, and excellent water retention capacity. Recent advances in polymer science have facilitated the development of Acacia gum-based self-healing hydrogels that possess the unique ability to autonomously repair structural damage through dynamic reversible interactions. These hydrogels mimic the extracellular matrix, maintain a moist wound environment, enhance cellular proliferation, facilitate oxygen diffusion, and provide controlled delivery of therapeutic agents. Self-healing hydrogels fabricated using Acacia gum have demonstrated significant potential in wound, burn, and ulcer management owing to their superior mechanical strength, injectability, antimicrobial activity, anti-inflammatory properties, and enhanced tissue regeneration capabilities. The incorporation of bioactive compounds, nanoparticles, growth factors, and therapeutic agents further improves their healing efficacy and clinical applicability. This review comprehensively discusses the global burden of wounds, burns, and ulcers; limitations of conventional wound management strategies; chemistry and properties of Acacia gum; principles of self-healing hydrogels; fabrication techniques; wound healing mechanisms; biomedical applications; recent advances; challenges; and future prospects of Acacia gum-based self-healing hydrogel systems for advanced wound care.},
        keywords = {Acacia Gum, Self-Healing Hydrogel, Wound Healing, Burn Management, Ulcer Treatment, Natural Polymers, Tissue Regeneration, Drug Delivery System.},
        month = {June},
        }