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@article{205149,
        author = {Sayali V. Kadam and Raju M. Patil},
        title = {A Review On Recent Developments, Design And Biological Applications Of Thiosemicarbazone Derivatives},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {5856-5878},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=205149},
        abstract = {Objective
Thiosemicarbazones typically bind through the sulphur and hydrazinic nitrogen atoms to interact as chelating ligands with metal ions. These metal complexes offer a fresh chance to broaden their application in many areas of medicine since they have been linked to the biological activities. Understanding the connections between thiosemicarbazone structures and activity, examining their behavioural mechanism, and maximizing character development are the objectives.
Methods
The several thiosemicarbazone derivatives have been prepared and designed by various scientists and these compounds were tested for their multiple biological activities like anticancer, antibacterial, antifungal, antimalarial, antioxidant, antiproliferative activities. On the basis of literature study of thiosemicarbazones, this review material has been collected.
Results 
The results of thiosemicarbazone derivatives shows various biologically active roles such as anticancer, antibacterial, antifungal, antimalarial, antioxidant, antiproliferative activities. The resulted thiosemicarbazone ligands can be utilized to create a further metal based thiosemicarbazone compounds. The main focus of the authors is on the cyclohexyl thiosemicarbazone derivatives and their pharmaceutical applications.  
Discussion 
Almost all the thiosemicarbazone based compounds shows biological potency but the results of the compounds vary according to the concentration of the substances. The addition of metal salts into the ligand are leading to form metal complexes and obviously shown a more ligating behaviour with the metal ion. 
Conclusion
The metal complexes show more potent pharmacological activity than its free ligands. The cyclohexyl group substitution attached on the thiosemicarbazone ligand gives more enhanced pharmacological activities. The therapeutic properties of the compounds and structural elucidation of the various thiosemicarbazone based compounds.},
        keywords = {Thiosemicarbazone, Biological activity, Human cell lines, Standard drugs, Anticancer activity, Antiproliferative activity, Coordination},
        month = {June},
        }