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@article{205345,
        author = {Ms.Aishwarya Madhukar Khose and Dr. Sagar S. Muley},
        title = {A COMPREHENSIVE REVIEW ON PULSATILE DRUG DELIVERY SYSTEM},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {6022-6033},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=205345},
        abstract = {Pulsatile Drug Delivery Systems represent a significant advancement in drug delivery technology, designed to synchronize drug release with the body’s natural rhythms or specific therapeutic needs. This comprehensive review explores the various approaches to PDDS. Time-controlled systems, such as single-unit capsules and multiarticulate systems, utilize mechanisms like diffusion, erosion, and osmosis to achieve controlled drug release. Stimuli-induced systems respond to environmental changes such as temperature or pH, triggering drug release through mechanisms like gel swelling or dissolution. Externally regulated systems, including electro-responsive, ultrasonically stimulated, and magnetically induced systems, offer precise control over drug delivery through external stimuli. The review delves into the mechanisms underlying each type of PDDS, highlights recent advancements and applications, and discusses the challenges and future directions for development. By aligning drug release with circadian rhythms or specific physiological conditions, PDDS hold the potential to enhance therapeutic efficacy and patient compliance across a range of medical conditions.},
        keywords = {Pulsatile Drug Delivery Systems (PDDS), Time-Controlled Drug Delivery, Chronotherapy, Circadian Rhythms, Therapeutic Efficacy.},
        month = {June},
        }