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@article{205558,
        author = {Dr.Raslamol K and FATHIMA FIDHA T K and MUHAMMED HIJAZ N K and RUKHSANA BASHEER and SAITHYA SUDHAKARAN and AMITHA SONY},
        title = {PHENYL ETHYL RESORCINOL: CHEMISTRY, SYNTHESIS, TYROSINASE INHIBITION AND EMERGING THERAPEUTIC APPLICATIONS—A COMPREHENSIVE REVIEW},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {6975-6989},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=205558},
        abstract = {Hyperpigmentation disorders such as melasma, solar lentigines, and post-inflammatory hyperpigmentation are primarily associated with excessive melanin production mediated by tyrosinase. Limitations of conventional depigmenting agents have stimulated interest in safer and more effective alternatives. This review evaluates the chemistry, mechanism of action, formulation approaches, biological efficacy, safety, and commercial potential of Phenyl Ethyl Resorcinol (PER) as a skin-lightening agent. PER is a synthetic resorcinol derivative with potent tyrosinase inhibitory and antioxidant activities. The 1,3-dihydroxy resorcinol core is crucial for copper-ion binding at the tyrosinase active site, while the phenylethyl substituent enhances lipophilicity and biological activity. PER exhibits significantly greater depigmenting efficacy than conventional agents such as kojic acid and arbutin. Advanced delivery systems including nanoliposomes, transfersomes, invasomes, and nanostructured lipid carriers have improved its stability, skin penetration, and therapeutic performance. Clinical studies have demonstrated visible reductions in pigmentation and improved skin tone with excellent dermal tolerability. Phenyl Ethyl Resorcinol is a highly effective and safe tyrosinase inhibitor with considerable potential in dermatological and cosmeceutical applications. Its superior efficacy, multifunctional mechanism of action, and compatibility with advanced nanocarrier systems position it as a promising next-generation agent for the management of hyperpigmentation disorders.},
        keywords = {Phenyl Ethyl Resorcinol; Tyrosinase Inhibitor; Melanogenesis; Hyperpigmentation; Skin Whitening; Resorcinol Derivatives; Nanoliposomes; Transferosomes; Cosmetic Chemistry; Cosmeceuticals.},
        month = {June},
        }