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@article{205648,
        author = {Sk. Shakeela and E. Sai Chandu and Y.V.L. Keerthy and R. Keerthi},
        title = {MEDICAL APPLICATIONS OF N-ACETYLCYSTEINE (NAC): MECHANISMS OF ACTION AND CLINICAL EFFECTIVENESS},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {7586-7588},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=205648},
        abstract = {N-acetylcysteine (NAC) is a synthetic derivative of the amino acid L-cysteine with well-established antioxidant, mucolytic, and cytoprotective properties. Initially introduced as a mucolytic agent, NAC later became the standard antidote for acetaminophen (paracetamol) poisoning because of its ability to replenish intracellular glutathione stores [1,2]. Over recent decades, its therapeutic applications have expanded into pulmonology, hepatology, nephrology, psychiatry, reproductive medicine, and oncology [3,4]. NAC exerts its effects through multiple mechanisms, including glutathione restoration, direct scavenging of reactive oxygen species, modulation of inflammatory pathways, and regulation of cellular signaling [3,5]. While strong clinical evidence supports its use in acetaminophen overdose and selected respiratory diseases, evidence for many emerging indications remains limited or inconsistent [6]. This review examines the pharmacology, mechanisms of action, clinical applications, safety profile, and therapeutic effectiveness of NAC across a broad range of medical conditions.},
        keywords = {N-acetylcysteine, NAC, glutathione, antioxidant, acetaminophen toxicity, oxidative stress.},
        month = {June},
        }