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@article{205806,
        author = {Leena Narute and Pratiksha Mohite and Bhagwat Meher and Amrata Mantri and Dr. Dhanajay Ghodake},
        title = {The Development of An Innovative Intelligent Method Based on Hydrogel},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {1},
        pages = {8304-8309},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=205806},
        abstract = {Smart hydrogels, which can respond to stimuli and adapt to external inputs, have emerged as an exciting research topic in biomedical engineering. They have proven indispensable in human health care and the pharmaceutical industry because they can selectively release drugs under specific conditions. Intelligent hydrogels, particularly intelligent hydrogels, may detect physiological triggers and deliver drugs at the site of action. To control swelling, hydrogel-based drug delivery systems employ temperature-responsive random copolymers of poly(N-isopropylacrylamide) and poly (vinyl pyrrolidinone). These hydrogels have low critical solution temperatures, which makes them suitable for smart drug delivery applications. Two model drugs, diclofenac sodium and procaine HCl, were trapped within these xerogels. Modulated differential scanning calorimetry, ATR-FTIR, and AFM were used to investigate the effects of medication on xerogels properties. Drug dissolution tests found that higher temperatures caused delayed release. Conventional therapies have limitations that need the use of controlled drug delivery systems. Hydrogel technology has become an essential component of human health care, with the pharmaceutical industry developing cutting-edge hydrogel-based treatments. This review examines the role of polymers and nanocomposite hydrogels. The study developed a constructed drug delivery system (DDS) that can perform a variety of activities, including drug protection, self-regulated oscillatory release, and concentrated unidirectional distribution. Control is achieved by using a pH-sensitive hydrogel and a poly (hydroxyethyl methacrylate) (HEMA) barrier. The device was tested with two model pharmaceuticals, acid orange 8 and bovine serum albumin, and demonstrated targeted unidirectional release in a diffusion cell. The BI layered gate detects variations in environmental pH and generates an oscillating release pattern.},
        keywords = {Hydrogels, xerogels, temperature responsive, nanocomposite, pH sensitive.},
        month = {June},
        }