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@article{206301,
        author = {Ms. Pragati Pradeeprao Ingole and Mr. S. S. Koushik},
        title = {Formulation and Evaluation of Nano-emulgel for Skin Care},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {2},
        pages = {988-1000},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=206301},
        abstract = {The increasing demand for effective topical drug delivery systems has led to the development of advanced formulations that improve the therapeutic efficacy and cosmetic acceptability of skincare products. Nano-emulgels have emerged as a novel and promising drug delivery system by integrating the advantages of nano emulsions and hydrogels into a single formulation. Nano emulsions are thermodynamically or kinetically stable dispersions of oil and water stabilized by surfactants, with droplet sizes typically ranging between 20 and 200 nm. Their small droplet size enhances drug solubility, permeation through the skin, and bioavailability of active pharmaceutical ingredients. However, their low viscosity limits their retention time on the skin surface. Incorporating nano emulsions into a gel matrix overcomes this limitation by improving viscosity, spread ability, stability, patient compliance, and ease of application.
Nano-emulgels have attracted significant attention in dermatological and cosmetic applications because they provide sustained drug release, enhanced skin penetration, improved hydration, and reduced systemic side effects. These formulations are particularly suitable for delivering hydrophobic bioactive compounds such as curcumin, vitamin E, coenzyme Q10, retinol, tea tree oil, essential oils, and various herbal extracts used in skincare. The gel matrix also imparts cooling effects, non-greasy texture, and better aesthetic appeal, making nano-emulgels highly acceptable to consumers.
The present study aims to formulate and evaluate a nano-emulgel intended for skin care by selecting suitable oils, surfactants, co-surfactants, gelling agents, preservatives, and active ingredients. The formulation is characterized through comprehensive pre-formulation studies, including organoleptic evaluation, solubility analysis, compatibility assessment, pH determination, viscosity measurement, droplet size analysis, zeta potential, spreadability, drug content estimation, in vitro drug diffusion, skin irritation studies, and stability testing. These evaluations ensure the development of a stable, safe, and effective topical dosage form with enhanced therapeutic performance.
The findings indicate that nano-emulgels offer considerable advantages over conventional creams, ointments, and gels by improving drug penetration, prolonging residence time on the skin, and providing controlled release of active ingredients. Furthermore, the incorporation of nanotechnology into topical formulations represents an innovative strategy for developing next-generation skincare products with superior efficacy and patient acceptability. Nano-emulgels therefore hold immense potential as an advanced topical delivery platform for cosmetic, dermatological, and pharmaceutical applications.},
        keywords = {},
        month = {July},
        }