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@article{207107,
        author = {Dr. Rupak Roy and Pranati Das and Shaurya Miteshkumar Patel},
        title = {Plant-Derived Compounds as Inhibitors of Quorum Sensing and Biofilm Formation in Antibiotic-Resistant Bacteria: Mechanisms, Therapeutic Potential, and Future Perspectives},
        journal = {International Journal of Innovative Research in Technology},
        year = {2026},
        volume = {13},
        number = {2},
        pages = {4183-4197},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=207107},
        abstract = {Antimicrobial resistance (AMR) has emerged as one of the most pressing global health challenges, significantly compromising the effectiveness of conventional antibiotics. A major contributor to persistent bacterial infections is the formation of biofilms, highly structured microbial communities embedded within an extracellular polymeric substance (EPS) matrix that restricts antibiotic penetration and facilitates resistance. Quorum sensing (QS), a bacterial cell-to-cell communication system, plays a central role in regulating biofilm development, virulence factor production, and coordinated bacterial behavior. Consequently, targeting QS rather than bacterial viability has gained considerable attention as a promising anti-virulence strategy. This review comprehensively summarizes the potential of plant-derived compounds as natural inhibitors of quorum sensing and biofilm formation in antibiotic-resistant bacteria. Major classes of phytochemicals, including flavonoids, phenolics, terpenoids, alkaloids, coumarins, and organosulfur compounds, are critically discussed with respect to their chemical characteristics, structure–activity relationships, molecular targets, and mechanisms of action. Their ability to interfere with signal molecule synthesis, receptor binding, extracellular polymeric substance production, bacterial adhesion, and virulence gene expression is highlighted. Furthermore, recent evidence supporting synergistic interactions between phytochemicals and conventional antibiotics is examined, demonstrating their potential to restore antibiotic efficacy while reducing selective pressure for resistance development. The review also discusses current limitations, including poor bioavailability, lack of standardization, limited clinical validation, and toxicity concerns, while highlighting emerging opportunities involving nanotechnology, molecular docking, artificial intelligence, and multi-omics approaches. Overall, plant-derived quorum sensing inhibitors represent promising adjunctive therapeutics that may complement existing antimicrobial strategies and help address the growing burden of antimicrobial resistance.},
        keywords = {Antimicrobial resistance, Biofilm inhibition, Quorum sensing, Phytochemicals, Anti-virulence therapy},
        month = {July},
        }