Clinical Effectiveness of PET/CT, PET, CT and MRI for Breast, Cervical, Head and Neck, Gastric and Lung Cancer-A Systematic Review and Meta-analysis
Author(s):
Dr.Pudi Nagaseshu, Kavita Kachroo, Jitendar Sharma, Arvind Bhushan, Aamir Sohail, Kavita Rajsekhar
Keywords:
Positron emission tomography with computer tomography (PET/CT), pelvic node, meta-analysis, Diagnostic test accuracy, sensitivity and specificity.
Abstract
Back ground: We performed a systematic review and meta-analysis to assess the accuracy of PET/CT, PET, CT and MRI for the detection of Breast cancer, Cervical cancer, Head and Neck cancer, Gastric cancer and Lung Cancer. Methods: Electronic databases were searched for studies assessing the sensitivity and specificity of PET/CT, PET, CT and MRI. A total of 345 articles from 61 meta- analysis and 3 HTA’s were included in this review. Revman software was used to assess the sensitivity, specificity. The Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2). Results: Total number of studies included in this systematic review and meta-analysis are 345 studies comprising of patients with Cervical cancer, Breast cancer, Head and Neck cancer, Gastric cancer and Lung cancer. The pooled sensitivity and specificity estimate of PET/CT, PET, CT and MRI for detecting above mentioned five cancers. After pooling all studies of CT, MRI, PET and PET/CT for cervical cancer the Forest plot of sensitivity and specificity of CT 0.62 (0.57, 0.67), 0.92 (0.57, 0.67), MRI 0.52 (0.49,0.55), 0.96 (0.95, 0.96) PET 0.90 (0.86,0.93) 0.93(0.91, 0.94) and PET/CT 0.65(0.62, 0.68) 0.97(0.97,0.98) in detecting LN metastases cervical cancer Tumors staging like IA, IB II A, II B, IIIA and IVA in cervical cancer with 95% CI. After pooling all studies, of CT, MRI, PET and PET/CT for Breast cancer the Forest plot of sensitivity and specificity of CT 0.87 (0.85, 0.89), 0.35 (0.33,0.38) MRI 0.97 (0.94, 0.98), 0.88(0.84, 0.91) PET 0.89 (0.86,0.90) 0.91(0.89, 0.93) and PET/CT 0.86(0.83, 0.88) 0.91(0.89, 0.93) in detecting local recurrences, lesion basis, distant metastases, and breast lesions in Breast cancer with 95 % CI After pooling all studies, of CT, MRI, PET and PET/CT for Head and Neck cancer the Forest plot of sensitivity and specificity of CT 0.81(0.77,0.85), 0.72(0.70, 0.74) MRI 0.77(0.74,0.79), 0.78(0.77,0.79) PET 0.20 (0.16, 0.25) 0.94(0.92, 0.96) and PET/CT 0.84(0.82,0.86) 0.88(0.86,0.89) in detecting Lymph node metastasis, detection of recurrence in patients and detecting neck levels I, II, and III with head and neck cancer Head and neck cancer with 95 % CI. After pooling all studies of CT, MRI, PET and PET/CT for Gastric cance
Article Details
Unique Paper ID: 150825

Publication Volume & Issue: Volume 7, Issue 10

Page(s): 89 - 99
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