INSULIN-LIKE GROWTH FACTOR AND PROSTATE CANCER RISK
Author(s):
Surajkumar Shivajirao Choukate, Shyamlila B. Bavage, Nandkishor B. Bavage
Keywords:
prostate cancer,insulin-like growth factor; insulin-like growth factor binding protein, meta-analysis.
Abstract
Insulin-like growth factors (IGF-I, IGF-II) and their binding proteins (IGFBP-1–6) important role in cell proliferation, differentiation and apoptosis, suggesting possible involvement in carcinogenesis. Several epidemiological studies show the associations of IGFs with prostate cancer .We searched the published literature for all studies related with the levels of IGFs with prostate cancer. We performed random effects meta-analysis to calculate the summary odd ratios. The number of studies (prostate cancer cases) included in each meta-analysis were 42 (7,481) IGF-I; 10 (923) IGF-II; 3 (485) IGFBP-1; 5 (577) IGFBP-2; 29 (6,541) IGFBP-3 and 11 (3,545) IGF-1: IGFBP-3 ratio. The pooled odds ratios (95%confidence intervals) per standard deviation increase in peptide were: IGF-I, OR 5 1.21 (1.07, 1.36); IGF-II, OR 5 1.17(0.93,1.47) IGFBP-1, OR 5 1.21 (0.62, 2.33); IGFBP-2, OR 5 1.18 (0.90, 1.54); IGFBP-3, OR 5 0.88 (0.79, 0.98); IGFI:IGFBP-3 ratio, OR 5 1.10 (0.97, 1.24).There was weak evidence that associations of the IGF-I and IGFBP-3 with prostate cancer were stronger for the advanced disease. Our meta-analysis confirms that the raised circulating lGF-I is positively associated with prostate cancer risk.
Article Details
Unique Paper ID: 152365

Publication Volume & Issue: Volume 8, Issue 3

Page(s): 31 - 38
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