THERAPEUTIC EFFECT OF AGMATINE ON NEUROLOGICAL DISORDERS AS DEPRESSION LIKE BEHAVIOUR IN RATS AND MICE
Author(s):
Poonam R. Pardhi, Rupali A. Deshmukh, Pranali J. Bhasker, Pragati G.Zalwade, Vipin T. Wankhede, Narendra N.Lanjewar, Pranita P. Agrawal
Keywords:
Agmatine, L-arginine, Arginine decarboxylation, Neuromodulator, Neuroprotective, Nitric oxide synthesis, CNS, Neurotransmitter system, Depression, Anxiety, Hypoxia, Ion channels, Antidepressant.
Abstract
We attempted to undertake our investigation on antidepressant activity of agmatine. Agmatine is chemical substance which is naturally created from the amino acid arginine and its formed by the enzymatic decarboxylation of L-arginine by arginine decarboxylation.[1] It is an endogenous neuromodulator that emerges as a potential agent to manage diverse central nervous system (CNS) disorders. Consistent with its neuromodulatory and neuroprotective properties, there is increasing number f preclinical studies demonstrating the beneficial effects of exogenous agmatine administration on depression, anxiety, hypoxic etc.[2] It has been shown to exert modulatory action at multiple molecular targets, like neurotransmitter system, ion channel, nitric oxide synthesis (NOS) and polyamine metabolism and this provides bases for further researchinto potential applications[3] The aim of this review is to summarize the knowledge about the effects of agmatine as antidepressant in CNS and point out its potential as new pharmacological treatment for diverse neurological and neurodegenerative diseases.
Article Details
Unique Paper ID: 152467

Publication Volume & Issue: Volume 8, Issue 3

Page(s): 533 - 538
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