Priya V. Gaikwad, Deepak A. Joshi, Shyamlila B. Bavage, Nandkishor B. Bavage
The brain is tightly segregated from the circulating blood by a unique membranous barrier Circle graphs are used to show the blood-brain barrier (BBB), many pharmaceuticals unable efficiently delivered to, or sustained inside the brain; hence, they are ineffective in treating cerebral diseases. Therefore, drug delivery methods that may provbrain delivery, or eventually preferential brain delivery (i.e., brain targeting), are of particular interest. To attain successful delivery, an understanding of the major structural, enzymatic, and active transport aspects related to the BBB, and of the issues related to lipophilicity and its major role in CNS entry, is critical. During few last years, considerable effort was focused in the field of brain-targeted drug delivery. Numerous more or less sophisticated approaches, such as intracerebral delivery, intracerebroventricular delivery, intranasal delivery, BBB disruption, nanoparticles, receptor mediated transport (vector-mediated transport or ‘chimeric’ peptides), cell-penetrating peptides, prodrugs, and chemical delivery systems, have been attempted. These approaches may offer more intriguing possibilities for brain delivery and targeting, but only few have reached the phase where they may provide safe and effective human applications.
Article Details
Unique Paper ID: 152405

Publication Volume & Issue: Volume 8, Issue 3

Page(s): 189 - 194
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