The in vitro anti-tumor efficacy of methanolic leaf extract of Exoecaria Agallocha in cancer cell lines of different tissue origin.

The in vitro anti-tumor efficacy of methanolic leaf extract of Exoecaria Agallocha in cancer cell lines of different tissue origin.
Author(s):
Dr. Rashmi Mohapatra
Keywords:
cytotoxicity, Cancer cell line, MTT Assay. Exoecaria agallocha
Abstract
The main goal of this study was to evaluate the antiproliferative activities of leaf extracts of Exoecaria agallocha on cancer cell lines of different tissue origin i.e. Breast, Ovary, Cervix, Melanoma, Colon, and Glioma. The methanolic leaf extract was concentrated to yield the crude extract, which was diluted in DMSO as per the desired concentration. The cytotoxic potential of the extracts was determined by 3-(4, 5-dimethylthiazole-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) Assay. The leaf extract exhibited significant cytotoxicity in vitro in majority of the cancer cell lines taken for study with IC50 values ranging from 13 - 20µg/ml except melanoma cells. Concurrently the cells were exposed to Adriamycin, a chemotherapy medication that is in use for treatment of cancer and both IC50 value was compared to evaluate the efficacy of the leaf extract. The result suggest more study on the phytoconstituent of this plant to explore promising anticancer drugs.
Article Details
Unique Paper ID: 152624 Publication Volume & Issue: Volume 8, Issue 3 Page(s): 970 - 974
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