FORMULATION AND EVALUATION OF ORAL IN-SITU GEL OF ESOMEPRAZOLE
Author(s):
Duddela Yamini, Pati. Sowmya, Bandi Manjula, Shaik Ayesha, K. Jyothirmayee
Keywords:
‘In situ gel’, Esomeprazole, Sodium alginate, Methyl paraben.
Abstract
The ‘In situ gel’ system emerged as one of the best Novel Drug Delivery System used for sustain and control drug delivery by its special characteristic feature of ‘Sol to Gel’ transition. Generally Esomeprazole is used as Proton pump inhibitor which belongs to class II of BCS Classification i.e. ., Low solubility and High permeability. The half life of drug is found to be less than 2 hrs, so in order to prevent repetitive administration of drug and to improve patient compliance (Bed ridden patients), the present study focus on formulation and Evaluation of Sustain release of oral ‘In situ gel’. Sodium alginate is used as Gelling polymer and Calcium carbonate was used as a cross linking agent. Other polymers such as Pectin, HPMC, and PEG 4000 are used to enhance the gelling capacity and also act as drug release retarding polymers. Methyl paraben is used as Preservative and sorbitol is used as sweetening agent. Sodium bicarbonate and calcium carbonate contributes to floating capability. Totally Nine formulations are prepared by varying different concentrations of Sodium alginate, PEG 4000 and HPMC. These are further evaluated for Viscosity, Gelling Time, Floating Time, Assay and Invitro release studies in order to select the best optimized formulation.
Article Details
Unique Paper ID: 153455

Publication Volume & Issue: Volume 8, Issue 7

Page(s): 259 - 266
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