FORMULATION, DEVELOPMENT AND OPTIMIZATION OF FLOATING SUSTAIN RELEASE TABLETS OF DOMPERIDONE FOR THE EFFECTIVE TREATMENT OF ANTIEMETIC DURING CHEMO THERAPY
Author(s):
Rohit kumar, Ashutosh Tripathi
Keywords:
Floating sustain release Tablets, Domperidone, Anti-emetics, Chemotherapy
Abstract
Objective- Formulation Development and optimization of Domperidone SR floating tablets for treatment of chemotherapy patient for continued emesis & maintaining a certain concentration of the administered a drug over a specific period of time into the patients system while reducing possible side effects. METHOD- The wet-granulation process was utilised to enhance the formulation of oral floating SR tablets. In this work, we created gastroretentive floating SR tablets for Domperidone using three distinct polymers: HPMC K4M, HPMC K15M, and HPMC K100M. The goal of this study is to enhance and assess the in vitro and in vivo performance of manufactured floating SR tablets. RESULT- The produced tablets were analysed and found to have excellent physicochemical properties. The effects of different HPMC grades at varied concentrations on drug release and floating qualities were investigated. All of the prepared batches demonstrated good in vitro buoyancy. CONCLUSION- The pills stayed buoyant for 12 hours. The optimal formulation (F8), consisting of HPMC K100M, was chosen based on in vitro drug release and phyco-chemical properties.
Article Details
Unique Paper ID: 153517

Publication Volume & Issue: Volume 8, Issue 7

Page(s): 451 - 456
Article Preview & Download


Share This Article

Conference Alert

NCSST-2021

AICTE Sponsored National Conference on Smart Systems and Technologies

Last Date: 25th November 2021

SWEC- Management

LATEST INNOVATION’S AND FUTURE TRENDS IN MANAGEMENT

Last Date: 7th November 2021

Latest Publication

Go To Issue



Call For Paper

Volume 9 Issue 10

Last Date for paper submitting for March Issue is 25 March 2023

About Us

IJIRT.org enables door in research by providing high quality research articles in open access market.

Send us any query related to your research on editor@ijirt.org

Social Media

Google Verified Reviews

Contact Details

Telephone:6351679790
Email: editor@ijirt.org
Website: ijirt.org

Policies

Important Links

Browse Rsearch papers