FORMULATION, DEVELOPMENT AND OPTIMIZATION OF FLOATING SUSTAIN RELEASE TABLETS OF DOMPERIDONE FOR THE EFFECTIVE TREATMENT OF ANTIEMETIC DURING CHEMO THERAPY
Author(s):
Rohit kumar, Ashutosh Tripathi
Keywords:
Floating sustain release Tablets, Domperidone, Anti-emetics, Chemotherapy
Abstract
Objective- Formulation Development and optimization of Domperidone SR floating tablets for treatment of chemotherapy patient for continued emesis & maintaining a certain concentration of the administered a drug over a specific period of time into the patients system while reducing possible side effects. METHOD- The wet-granulation process was utilised to enhance the formulation of oral floating SR tablets. In this work, we created gastroretentive floating SR tablets for Domperidone using three distinct polymers: HPMC K4M, HPMC K15M, and HPMC K100M. The goal of this study is to enhance and assess the in vitro and in vivo performance of manufactured floating SR tablets. RESULT- The produced tablets were analysed and found to have excellent physicochemical properties. The effects of different HPMC grades at varied concentrations on drug release and floating qualities were investigated. All of the prepared batches demonstrated good in vitro buoyancy. CONCLUSION- The pills stayed buoyant for 12 hours. The optimal formulation (F8), consisting of HPMC K100M, was chosen based on in vitro drug release and phyco-chemical properties.
Article Details
Unique Paper ID: 153517

Publication Volume & Issue: Volume 8, Issue 7

Page(s): 451 - 456
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