FORMULATION AND EVALUATION OF DEFLAZACORT LOADED SOLID LIPID MICROPARTICLES
Author(s):
Sandeep Dagar, Ruchi Rawat, Pinki
Keywords:
colloidal drug carrier system, SLM’s, Deflazacort, entrapment efficiency, drug content, drug delivery.
Abstract
Micro particulates are the colloidal system ranges from 1- 1000 micrometer they can be erodible, non-erodible or ion-exchange resins. These systems were developed to conquer solubility problems of poorly soluble drugs as well as for long-acting injectable depot formulations and specific drug targeting options. The drug is released from the particles through diffusion, chemical reaction, polymer degradation, or ion exchange mechanism. The main objective for these systems was to improve the bioavailability and enhance the sustainability of drug within the body. The in vitro and in vivo studies have shown that this dosage form holds great promise for sustained drug release. The thesis summarizes the present manufacturing methods and the materials used for these delivery systems. The purpose of the present study was to develop solid lipid microparticles (SLMs) of Deflazacort by investigating the relationship between drug/lipid ratios. SLMs were successfully prepared by Solvent emulsification-based method followed by ultrasonication using. Morphology, particle size, entrapment efficiency, drug content, and drug release behavior were investigated, respectively. As a result, the microparticle designed showed nearly spherical particles. The EE (%) and DC (%) could reach up to 89.5% and 93.3%, respectively. In vitro release studies show as lipid concentration increases prolonged release of drug from SLM up to 24 hours was observed. The distribution and penetration pathways of the particulate delivery systems are also described. The applications of drug-loaded particles are presented with focus on enhancing the bioavailability. Productive goals of innovative difficulties will bring about a predominant measurements structure for desired site of action like topical and intraocular ophthalmic application.
Article Details
Unique Paper ID: 153690

Publication Volume & Issue: Volume 8, Issue 8

Page(s): 234 - 241
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