MICROWAVE ASSISTED TRICHLORO TRIAZINE CATALYZED SYNTHESIS OF 2-(4-((4-CHLOROPHENYL) SULFONYL) PHENYL)-5-PHENYLOXAZOLES

MICROWAVE ASSISTED TRICHLORO TRIAZINE CATALYZED SYNTHESIS OF 2-(4-((4-CHLOROPHENYL) SULFONYL) PHENYL)-5-PHENYLOXAZOLES
Author(s):
Omprakash S. Chavan
Keywords:
Hippuric acid, Oxazole, Trichloro triazine (TCT), Microwave method
Abstract
Starting as an Amino acid (Hippuric acid) 1 cyclized by using cyanuric acid (TCT) as environmentally benign catalyst to 2-phenyloxazol-5(4H)-one 2 further treated with aromatic aldehyde Friedel-Craft reaction to benzoyl amino ketones 3 and finally cyclized gives good yields of 2-(4-((4-chlorophenyl) sulfonyl) phenyl)-5-phenyloxazoles 4a-h under microwave condition. The reaction performed in less time of reaction, cleaner no side product, good to excellent yield of product.
Article Details
Unique Paper ID: 153946 Publication Volume & Issue: Volume 8, Issue 9 Page(s): 292 - 297
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