Role of TLX1/HOX11 in transcriptional activation of genes relevant to Leukemogenesis
Author(s):
VAISHALI SHUKLA
Keywords:
T-cell acute lymphoblastic leukaemia (T-ALL), TLX1/HO11gene, TLX1-T-cell leukaemia homeobox protein 1
Abstract
T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive malignant neoplasm of the T-cells. T-cells a type of white blood cells originates in bone marrow and develop in thymus. T-ALL accounts for ∼20% of all cases of ALL. It is aggressive in nature and progresses very quickly. Although, causative factors of T-ALL are not much explored, few reports suggest that TLX1 is found inappropriately expressed in leukemic cases and associated with leukemogenesis. TLX1 encoding the transcription factor T-cell leukaemia homeobox protein 1. Chromosomal translocation is associated with the leukemic transformation of T-cells and 30% of total T-ALL cases are found to be positive for TLX1 translocation (10:14). Intrigued by this, we are intended to understand the possible role of 10:14 chromosomal translocation and thus the TLX1 activation and TLX1 induced malignancies complex intracellular changes in genes like NOTCH1, PTPN2, WT1, BCL11b, PTEN, PHF6 genes are altered which are involved in tumour cell survival and progression. This TF regulates a number of genes by binding to the promoter region in the regulatory region of the target gene.
Article Details
Unique Paper ID: 154594

Publication Volume & Issue: Volume 8, Issue 11

Page(s): 688 - 693
Article Preview & Download


Share This Article

Conference Alert

NCSST-2021

AICTE Sponsored National Conference on Smart Systems and Technologies

Last Date: 25th November 2021

SWEC- Management

LATEST INNOVATION’S AND FUTURE TRENDS IN MANAGEMENT

Last Date: 7th November 2021

Go To Issue



Call For Paper

Volume 8 Issue 4

Last Date 25 September 2021

About Us

IJIRT.org enables door in research by providing high quality research articles in open access market.

Send us any query related to your research on editor@ijirt.org

Social Media

Google Verified Reviews

Contact Details

Telephone:6351679790
Email: editor@ijirt.org
Website: ijirt.org

Policies