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@article{155943,
        author = {VENKATESAN VINAYAGAM M.PHIL and Shanmugam Rajalakshmi and M.N.ARUMUGHAM},
        title = {Synthesis, characterization, DNA binding, anticancer and antimicrobial activity , DFT, Molecular docking studies of Copper (II) complexes with Neocuproine and L-Ornithine},
        journal = {International Journal of Innovative Research in Technology},
        year = {},
        volume = {9},
        number = {2},
        pages = {292-304},
        issn = {2349-6002},
        url = {https://ijirt.org/article?manuscript=155943},
        abstract = {he new complex, have been synthesized and characterized. The metal complex have been characterized by elemental analysis, UV, IR, conductivity measurements, EPR and magnetic studies. The interaction of complex with CT-DNA was investigated by carrying out UV- vis absorption spectrum and fluorescence ethidium bromide displacement experiment. The DNA-binding constants Kb of complex were calculated to be 2.1059×104 M-1. The result indicated that these complexe interact with CT-DNA through intercalative mode. Competitive studies with ethidium bromide (EB) further showed that the complexes bind to DNA probably via intercalation. The anti-microbial activities and MTT-Assy studies have also been studied.In anti-microbial activity the complex showed good anti-microbial activity higher in gram positive, gram negative bacteria and fungi. The structure of the present complex  has been optimized using the DFT/ B3LYP/6-31G(d,p)/LANL2DZ level of theory and cyclic voltametric studies,   Molecular docking analysis was carried out.},
        keywords = {Neocuproine; DFT; DNA-binding; MTT Assay; L-Ornithine, docking.},
        month = {},
        }