Synthesis, characterization, DNA binding, anticancer and antimicrobial activity , DFT, Molecular docking studies of Copper (II) complexes with Neocuproine and L-Ornithine
Author(s):
VENKATESAN VINAYAGAM M.PHIL, Shanmugam Rajalakshmi, M.N.ARUMUGHAM
Keywords:
Neocuproine; DFT; DNA-binding; MTT Assay; L-Ornithine, docking.
Abstract
he new complex, have been synthesized and characterized. The metal complex have been characterized by elemental analysis, UV, IR, conductivity measurements, EPR and magnetic studies. The interaction of complex with CT-DNA was investigated by carrying out UV- vis absorption spectrum and fluorescence ethidium bromide displacement experiment. The DNA-binding constants Kb of complex were calculated to be 2.1059Ă—104 M-1. The result indicated that these complexe interact with CT-DNA through intercalative mode. Competitive studies with ethidium bromide (EB) further showed that the complexes bind to DNA probably via intercalation. The anti-microbial activities and MTT-Assy studies have also been studied.In anti-microbial activity the complex showed good anti-microbial activity higher in gram positive, gram negative bacteria and fungi. The structure of the present complex has been optimized using the DFT/ B3LYP/6-31G(d,p)/LANL2DZ level of theory and cyclic voltametric studies, Molecular docking analysis was carried out.
Article Details
Unique Paper ID: 155943

Publication Volume & Issue: Volume 9, Issue 2

Page(s): 292 - 304
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