Preliminary studies, anti-oxidants, acute oral toxicity and anti-arthritis activity of Cassia Sophera
Author(s):
Akanksha Mishra, RS Pawar, Hargovind Garg
Keywords:
Cassia Sophera, Arthritis, Anti-oxidant, Acute oral toxicity
Abstract
To determine the ameliorative potential of ethanol extract of Cassia sophera(C.sophera) against in-vitro antioxidant and in-vivo acute oral toxicity and arthritis using albino wistar rats, and its possible mechanism of action. Antioxidant potential was evaluated by DPPH and reducing power method and results was found to be significant. Albino Wistar rats (200±20g) under standard controlled conditions (22 ± 2°C, 30% humidity and 12:12 light/dark cycle). Acute toxicity studies was performed according to Organisation of Economic Co-operation and Development guidelines and no mortality was found. For anti-arthritis activity, the animal’s groups were divided into 6 groups (n = 6/group) and assigned as control, reference standard (Indomethcine) and, group III and IV animal received crude extracts of C.sophera. Paw size was measured till 28th days and analysed for haematological and histopathological parameter.At 28th day, C.sophera showed paw edema 3.705±0.281 at the dose 400mg/kg wt similar to reference drug. Thus, the present study revealed that the extract of C.sophera offered significant protection against anti-oxidants, acute oral toxicity and arthritis.
Article Details
Unique Paper ID: 156110

Publication Volume & Issue: Volume 9, Issue 2

Page(s): 900 - 905
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