EVALUTION OF THE ANTIDEPRESSANT ACTIVITY OF ETHANOLIC EXTRACT OF TAGETES ERECTA FLOWER USING ALBINO MICE
Author(s):
Anish kumar, Jyoti singh, Ramesh kumar singh
Keywords:
Forced swimming test, Tail suspension test, Anoxic stress tolerance test, Hole Board Test, Tagetes erecta flower.
Abstract
Different parts of plant Tagetes erecta (Asteraceae) have been habitually used for a number of disorder including fits, epileptic, fever, astringent as a carminative to relieve abdominal pain or distension or flatulence. The aim of study was to estimate antidepressants activity of ethanolic extract Tagetes erecta flower identification of Phytochemical analysis. The mice were administered with vehicle (12 ml/kg saline as a control), the extract of TEF (250 and 500 mg/kg body weight/rat/p.o.) and Standard drug, Diazepam (3mg/kg/rat) for 7 days., Tail Suspension Test (TST), Forced Swimming Test (FST), Hole Board Test (HBT) Actophotometer and Anoxic Tolerance Test (ATT) were conducted 70 min after the last administration of TEF extract determine to the antidepressant effects. Results showed that TEF herbal extract (500 and 250 mg/kg dose) significantly values (p< 0.01 and 0.0001) reduced duration of immobility test in TST and FST without affecting the locomotor action on open field test. It was also observed that Tagetes erecta flower extract significantly more (p< .05) anoxia stress acceptance time in a dose dependant & compared to effect control, but less than Diazepam treatment. The Tagetes erecta flower extract did not prove any noxious effects, and organ, weights, histological and hematological parameters were normal observed after 14 days treatment. In summery, TEF herbal extract administration considerably reduced the immobility in FST and TST.
Article Details
Unique Paper ID: 156579

Publication Volume & Issue: Volume 9, Issue 4

Page(s): 215 - 222
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