Author Login IJIRT Partner Network (IPN) Login

EVALUTION OF THE ANTIDEPRESSANT ACTIVITY OF ETHANOLIC EXTRACT OF TAGETES ERECTA FLOWER USING ALBINO MICE

  • Unique Paper ID: 156579
  • Volume: 9
  • Issue: 4
  • PageNo: 215-222
  • Abstract:
  • Different parts of plant Tagetes erecta (Asteraceae) have been habitually used for a number of disorder including fits, epileptic, fever, astringent as a carminative to relieve abdominal pain or distension or flatulence. The aim of study was to estimate antidepressants activity of ethanolic extract Tagetes erecta flower identification of Phytochemical analysis. The mice were administered with vehicle (12 ml/kg saline as a control), the extract of TEF (250 and 500 mg/kg body weight/rat/p.o.) and Standard drug, Diazepam (3mg/kg/rat) for 7 days., Tail Suspension Test (TST), Forced Swimming Test (FST), Hole Board Test (HBT) Actophotometer and Anoxic Tolerance Test (ATT) were conducted 70 min after the last administration of TEF extract determine to the antidepressant effects. Results showed that TEF herbal extract (500 and 250 mg/kg dose) significantly values (p< 0.01 and 0.0001) reduced duration of immobility test in TST and FST without affecting the locomotor action on open field test. It was also observed that Tagetes erecta flower extract significantly more (p< .05) anoxia stress acceptance time in a dose dependant & compared to effect control, but less than Diazepam treatment. The Tagetes erecta flower extract did not prove any noxious effects, and organ, weights, histological and hematological parameters were normal observed after 14 days treatment. In summery, TEF herbal extract administration considerably reduced the immobility in FST and TST.
Download article email to a friend

Cite This Article

  • ISSN: 2349-6002
  • Volume: 9
  • Issue: 4
  • PageNo: 215-222

EVALUTION OF THE ANTIDEPRESSANT ACTIVITY OF ETHANOLIC EXTRACT OF TAGETES ERECTA FLOWER USING ALBINO MICE

Related Articles

Impact Factor
8.01 (Year 2024)
UGC Approved
Journal no 47859

Join Our IPN

IJIRT Partner Network

Submit your research paper and those of your network (friends, colleagues, or peers) through your IPN account, and receive 800 INR for each paper that gets published.

Join Now

Latest Publication

Archive

View More

Recent Conferences

NCSEM 2024

National Conference on Sustainable Engineering and Management - 2024 Last Date: 15th March 2024

Submit inquiry