Protein Sequence Analysis and Homology Modeling Of the Human T-cell Leukemia
Author(s):
Uma Kumari, Tanishka Uttam
Keywords:
HTLV-1; T cell leukemia; carcinogenesis; miRNAs, Homology modelling, Molecular Docking,Structural Analysis
Abstract
The human deals with many diseases emerging from many sources, but only a few of them are curable. Diseases caused by viruses as sources are the most difficult ones to deal with. HTLV-1(Human T cell lymphotropic/leukaemia type-1) comes under retrovirus classification.In most cases, no sure cure is present till nowadays. The current status the estimated at 5 million to 10 million. The causative agents of both adult T cell leukaemia (ATL) and HTLV-1 Associated Myelopathy Spastic Paraparesis (HAM/TSP). The main geographical regions are the Southwestern part of Japan, Sub-Saharan Africa and South America. The initial stage of infection is unknown but certain studies show that the virus attack CD4+ T cells, CD34+, B lymphocytes, T lymphocytes and hematopoietic progenitor cells etc. Through an In-silicon approach for designing the drug against this protein expressed by HTLV-1 cells using bioinformatics database and software. Designing of ligands for substrate (HTLV-1) was performed.It was identified that the drug Allopathy Glatiramer, Plant-based drug Oleandrin and antibodies Doxycycline showed partially able to cure the T cell leukaemia virus replication protein structure.
Article Details
Unique Paper ID: 157287

Publication Volume & Issue: Volume 9, Issue 6

Page(s): 388 - 398
Article Preview & Download


Share This Article

Join our RMS



Conference Alert

NCSEM 2024

National Conference on Sustainable Engineering and Management - 2024

Last Date: 15th March 2024

Latest Publication

Call For Paper

Volume 11 Issue 1

Last Date for paper submitting for Latest Issue is 25 June 2024

About Us

IJIRT.org enables door in research by providing high quality research articles in open access market.

Send us any query related to your research on editor@ijirt.org

Social Media

Google Verified Reviews

Contact Details

Telephone:6351679790
Email: editor@ijirt.org
Website: ijirt.org

Policies

Important Links

Browse Rsearch papers