Protein Sequence Analysis and Homology Modeling Of the Human T-cell Leukemia

Uma Kumari; Tanishka Uttam

Protein Sequence Analysis and Homology Modeling Of the Human T-cell Leukemia

Authors: Uma Kumari, Tanishka Uttam

Unique Paper ID: 157287
Volume: 9
Issue: 6
PageNo: 388-398

Keywords: HTLV-1; T cell leukemia; carcinogenesis; miRNAs Homology modelling Molecular Docking Structural Analysis

Abstract:
The human deals with many diseases emerging from many sources, but only a few of them are curable. Diseases caused by viruses as sources are the most difficult ones to deal with. HTLV-1(Human T cell lymphotropic/leukaemia type-1) comes under retrovirus classification.In most cases, no sure cure is present till nowadays. The current status the estimated at 5 million to 10 million. The causative agents of both adult T cell leukaemia (ATL) and HTLV-1 Associated Myelopathy Spastic Paraparesis (HAM/TSP). The main geographical regions are the Southwestern part of Japan, Sub-Saharan Africa and South America. The initial stage of infection is unknown but certain studies show that the virus attack CD4+ T cells, CD34+, B lymphocytes, T lymphocytes and hematopoietic progenitor cells etc. Through an In-silicon approach for designing the drug against this protein expressed by HTLV-1 cells using bioinformatics database and software. Designing of ligands for substrate (HTLV-1) was performed.It was identified that the drug Allopathy Glatiramer, Plant-based drug Oleandrin and antibodies Doxycycline showed partially able to cure the T cell leukaemia virus replication protein structure.

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Cite This Article

ISSN: 2349-6002
Volume: 9
Issue: 6
PageNo: 388-398

Protein Sequence Analysis and Homology Modeling Of the Human T-cell Leukemia

Available:https://ijirt.org/Article?manuscript=157287

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UGC Approved
Journal no 47859

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