Molecular Docking And Dynamic Studies Human Anaplastic Lymphoma Kinase Domain

Uma Kumari; Sambit Majumdar; Sudarshan Gopinath

Molecular Docking And Dynamic Studies Human Anaplastic Lymphoma Kinase Domain

Authors: Uma Kumari, Sambit Majumdar, Sudarshan Gopinath

Unique Paper ID: 167617
Volume: 11
Issue: 3
PageNo: 1654-1659

Keywords: Human Anaplastic Lymphoma Kinase Structure analysis Homology modelling Biopython CB-Dock H-Dock

Abstract:
Lung cancer is one of the most common diseases in the world today. Early diagnosis of these conditions will facilitate more effective treatment plans for the patient. The 7R7R gene in ALK-positive non-small cell lung cancer is the subject of this study. In order to examine the activity and similarities of the 7R7R gene within the ALK gene in ALK-positive non-small cell lung cancer, the study currently offers a structure-based drug design strategy. Human ALK-positive cancer generally starts as lung cancer, but it can also start in the brain or breast, among many other regions of the body. About 5% of lung cancer patients also have ALK-positive lung cancer. As compared to lung cancer patients overall, approximately half of those with ALK-positive lung cancer receive a diagnosis before the age of 50. Many of these patients are in their 30s and 40s, but some are even in their teens and twenties. In this paper, we have used ERRAT tool to validate our structure. Also BioPython has been used to simplify our data and finally, the molecular docking study, to observe strong binding affinity of the active site of human anaplastic lymphoma kinase with a docking score.

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ISSN: 2349-6002
Volume: 11
Issue: 3
PageNo: 1654-1659

Molecular Docking And Dynamic Studies Human Anaplastic Lymphoma Kinase Domain

Available:https://ijirt.org/Article?manuscript=167617

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