IN VITRO ANTI-RHEUMATOID ARTHRITIS ACTIVITY OF POLYALTHIA KORINTI EXTRACTS
Author(s):
M. Satya Prasad, A. Krishna Satya
Keywords:
Polyalthia korinti, Rheumatoid arthritis, chronic inflammation, Protein denaturation
Abstract
Rheumatoid arthritis, the common human autoimmune disease is characterized by chronic inflammation in joints followed by pannus formation within filtered lymphocytes and fibrinoid joints of a synovial membrane with concomitant destruction of cartilage and bone. Denaturation of tissue proteins is a marker for inflammatory and arthritic diseases since most biological proteins lose their biological function when denatured. As a result, agents that prevent protein denaturation may be a promising target for anti-arthritis drug production. With this idea in mind, an in vitro test was conducted to determine the existence of anti-arthritic properties in plant extracts. In the present study, the protein denaturation bioassay was selected as one of the in vitro assessment of the anti-arthritic property of P.korinti leaves and bark extracts with a wide range of dose concentrations. Polyalthia korinti extracts prevented heat-induced protein denaturation in our sample. Out of all the extracts of P.korinti leaves methanol extract act as most potent inhibitor to prevent protein denaturation. This study promising target for anti-arthritis drug production.
Article Details
Unique Paper ID: 157318

Publication Volume & Issue: Volume 9, Issue 6

Page(s): 593 - 599
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