Assessment of Hepatoprotective and Antioxidant Activity of Achyranthes Aspera Against Ccl4 Induced Hepatic Damage In Swiss Albino Mice

Assessment of Hepatoprotective and Antioxidant Activity of Achyranthes Aspera Against Ccl4 Induced Hepatic Damage In Swiss Albino Mice
Author(s):
Ms. Juri knowar, Madhubanti Das, Jugen Kalita
Keywords:
Hepatoprotective, Antioxidant, Achyranthes aspera, Liver injury, Silymarin, Medicinal plant.
Abstract
The in vivo hepatoprotective and antioxidant effect of Achyranthes aspera was evaluated in carbon tetrachloride-induced hepatic injury model in Swiss albino mice. Effects of the methanolic leaf extracts of Achyranthes aspera (AAME) at a dose of 200 mg/kg body weight and 500 mg/kg body weight was tested for its efficacy on CCl4 (1ml/kg body weight) induced liver injury. Biochemical, histological and hepatic oxidative stress parameters were studied. Daily oral administration of AAME (500 mg/kg) reduced liver toxicity marker enzyme activity significantly as compared to the control. The results were also supported by the histopathological studies. Recovery of the liver tissue was observed in the highest dose (500 mg/kg) of AAME. The progression of liver damage could be inhibited by the antioxidant activities of AAME and the normal architecture of the liver could be preserved. The plant can therefore be a potential therapeutic candidate to treat liver injury.
Article Details
Unique Paper ID: 157951 Publication Volume & Issue: Volume 9, Issue 8 Page(s): 310 - 316
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