STRATEGIC TREATEMENT OF GLIOBLASTOMA IN MICE BY GOKHRU EXTRACTED SAPONINS
Author(s):
Sakshi Aole, Anjali Chourasiya, Dr. Pradeep Pal, Dr. Akanksha Jagwani, Dr. Vikas Jain
Keywords:
Abstract
Plant compounds called saponins have been proposed as potential anticarcinogens. Because of their chemical structure's amphiphilic nature, they have surface-active properties. The regulation of carcinogen-induced cell growth, direct cytotoxicity, immune-modulatory effects, and bile acid binding are some of the hypothesised mechanisms of saponins' anticarcinogenic actions. The anticarcinogenic properties of saponins from frequently eaten plant foods have not, however, been investigated. One of the most significant sources of dietary saponins is soy beans. They serve as the primary source of protein in many vegetarian diets. Our findings shown that human cancer cells were dose-dependently growth inhibited by soybean saponins at concentrations of 150–600 ppm (HCT-15). Additionally, viability was much diminished. The permeability of cell membranes was not increased by soybean saponins in a dose-dependent manner. Our findings shown that human cancer cells were dose-dependently growth inhibited by soybean saponins at concentrations of 150–600 ppm (HCT-15). Additionally, viability was much diminished. While gypsophilla saponin, a non-dietary saponin, enhanced permeability with increasing concentrations, soybean saponins did not increase cell membrane permeability in a dose-dependent manner. According to electron microscopy, the cell shape and interactions with the cell membrane of soybean and gypsophilla saponins vary.
Article Details
Unique Paper ID: 158599

Publication Volume & Issue: Volume 9, Issue 10

Page(s): 232 - 240
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