ANTIUROLITHIATIC ACTIVITY OF ETHANOLIC EXTRACT OF CUCUMIS SATIVUS FRUIT IN WISTAR RATS

ANTIUROLITHIATIC ACTIVITY OF ETHANOLIC EXTRACT OF CUCUMIS SATIVUS FRUIT IN WISTAR RATS
Author(s):
GADDAM SUSHMA
Keywords:
Cucumis sativus, Antiurolithiatic activity, Allopurinol, and Ethylene glycol (0.75 % v/v)
Abstract
The present study explores the antiurolithiatic activity of an ethanolic extract of the Cucumis Sativus (CS) fruit in Wistar rats. Ethylene glycol (0.75% v/v) induced calculi in Wistar rats. They have assessed various parameters like biochemical estimations of serum, urine, and kidney tissue homogenate and histopathological studies of a kidney. The treatment with doses of 200 mg/kg and 400 mg/kg of ethanolic extract of CS exerts dose-dependent anti-urolithic activity. A significant reduction in the deposition of kidney stone-forming constituents like calcium, oxalate, and phosphate was found in the kidneys. The Wistar rat’s kidney sections showed the presence of crystals, dilatation of tubules tubulorrhexis, and the epithelial recovered.
Article Details
Unique Paper ID: 158992 Publication Volume & Issue: Volume 9, Issue 11 Page(s): 108 - 112
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