Formulation and In-vitro Evaluation of Naratriptan Hydrochloride Sublingual Tablets

Formulation and In-vitro Evaluation of Naratriptan Hydrochloride Sublingual Tablets
Author(s):
L. Neelima, Ramya Teja. M, CH. Glory, B. Ayyappa Reddy, B. Vekateshwarlu naik, J. Samuel morise, Dr. J.N. Suresh Kumar
Keywords:
Naratriptan hydrochloride, Crospovidone, Croscarmellose Sodium, Sodium starch glycollate
Abstract
In the present work, an attempt has been made to develop Sublingual tablets of Naratriptan hydrochloride. In the present work Sodium starch glycollate, Crospovidone and Croscarmellose sodium were employed as super disintegrating agents to enhance the solubility and dissolution rate of selected drug molecule. All the formulations were prepared by direct compression method using 6mm punch on 8 station rotary tablet punching machine. The blend of all the formulations showed good flow properties such as angle of repose, bulk density, tapped density. The prepared tablets were shown good post compression parameters and they passed all the quality control evaluation parameters as per I.P limits. Among all the formulations F4 formulation showed maximum % drug release i.e., 99.16 % in 8 min hence it is considered as optimized formulation. The F4 formulation contains Crospovidone as superdisintegrate in the concentration of 2.5 mg.
Article Details
Unique Paper ID: 159356 Publication Volume & Issue: Volume 9, Issue 11 Page(s): 1178 - 1185
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