Overview on Pathogenesis and Role of Probiotics in Liver Fibrogenesis
Author(s):
Moganthan R, Abarnadevika A, Ariharasivakumar G, Swarnabala S, Deepika R
Keywords:
Liver fibrogenesis, Extracellular matrix proteins [ECM], Hepatic stellate cells (HSC), Probiotics.
Abstract
Liver fibrogenesis is generally marked by deposition of Extracellular matrix protein (ECM), which is a reason for majority of the long-term liver diseases. The most common causes of liver fibrogenesis are misuse of alcohol genetic abnormalities, hepatitis virus infections, autoimmunity, and other non-infectious illnesses including fatty liver. A chain of events results in the liver hardening, including the retention of inflammatory cells and the activation of collagen-producing cells inside the injured liver that destroys hepatocytes and ultimately lead to hepatic fibrogenesis, which hardens the liver. Extracellular matrix proteins [ECM], notably collagen type 1, which is largely produced by hepatic stellate cells, are deposited excessively in this condition, making it distinct (HSCs). Probiotics are effective, economical, and have no long-term detrimental effects. Probiotics are the therapeutic option for liver fibrogenesis. Probiotics have antioxidant potency to reduce the elevated degree of (ROS) reactive oxygen species because it is the major cause for HSCs activation and it will introduce the IL-10 which is act as a protective cytokine and it inhibits the inflammatory cytokines and decrease the protein deposition.
Article Details
Unique Paper ID: 159614

Publication Volume & Issue: Volume 9, Issue 12

Page(s): 465 - 474
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